Long-term brain volume trajectories and lifestyle associations in cognitively normal adults: the Brain-Stride study
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ID: 327790
2026
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Abstract
Abstract Brain aging is a major determinant of cognitive health, yet the extent of inter-individual variability in structural trajectories and its links to lifestyle factors remain incompletely understood. We conducted a single-center, prospective longitudinal cohort study within an urban academic health screening program in Japan (November 2006 to April 2021), with up to 15 years of follow-up. Among 10,209 individuals who underwent screening, those with more than 10 years of serial visits were eligible; 186 participants were excluded for major intracranial findings, 3 for cognitive decline during follow-up, and 3 for contraindications or ineligibility, yielding 653 cognitively normal adults (207 women [31.6%]; mean [SD] age at baseline, 55.1 [9.3] years). Participants underwent serial magnetic resonance imaging and Mini-Mental State Examination, and baseline assessment of lifestyle and vascular risk factors including body mass index (BMI), blood pressure, smoking exposure, and lipid profile. Annual percentage change in whole-brain and regional volumes was estimated using linear mixed-effects models after harmonization for scanner effects, and participants were categorized as rapid atrophy, typical, or atrophy-resistant based on percentile thresholds. Across 7,915 MRI scans, whole-brain volume decline accelerated from 0.24% per year in the 40s to 0.44% per year in the 70s. Individuals classified as rapid atrophy in their 40s exhibited decline rates of 0.46% per year, comparable to population averages in the 70s, whereas atrophy-resistant individuals in their 70s demonstrated rates as low as 0.27% per year. Faster whole-brain atrophy was associated with higher BMI (β = 0.027; 95% CI, 0.0058–0.049), greater smoking exposure (β = 0.032; 95% CI, 0.012–0.053), elevated diastolic blood pressure (β = 0.044; 95% CI, 0.021–0.067), and higher low-density lipoprotein (LDL) cholesterol (β = 0.043; 95% CI, 0.021–0.065) (all P < .01). Leveraging an uncommonly long and densely sampled longitudinal design, this study demonstrates that structural brain aging among cognitively normal adults follows highly heterogeneous trajectories, spanning marked decline to near-complete resistance. Modifiable lifestyle and vascular risk factors were associated with faster atrophy, supporting opportunities for risk stratification and targeted prevention strategies.
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| Authors | Shohei Fujita, Susumu Mori, Kengo Onda, Shouhei Hanaoka, Yukihiro Nomura, Takahiro Nakao, Akifumi Hagiwara, Yasuhiro Hagiwara, Hidemasa Takao, T. Yoshikawa, Osamu Abe |
| Journal | Brain communications |
| Year | 2026 |
| DOI |
10.1093/braincomms/fcag343
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| URL | |
| Keywords | Keywords not found |
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