miR160a-ARF4 module regulates the biosynthesis of Panax notoginseng saponins

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ID: 327490
2026
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Abstract
Panax notoginseng is an economically vital medicinal plant, prized for its bioactive P. notoginseng saponins (PNS) which possess significant therapeutic effects in cardiovascular and cerebrovascular diseases. Despite the elucidation of the core enzymatic steps in PNS biosynthesis, the post-transcriptional mechanisms that coordinate these metabolic fluxes remain largely obscure. This study explored the Pn-miR160a-ARF4 module as a pivotal regulation mode in the biosynthesis of PNS. Under methyl jasmonate (MeJA) stimulation, Pn-miR160a was significantly upregulated, subsequently targeting and cleaving the transcripts of auxin response factor 4 (PnARF4). This targeted silencing of PnARF4 effectively relieves its transcriptional repression, thereby promoting the expression of downstream biosynthetic genes and increasing PNS yield. By integrating hormonal signaling with miRNA-mediated gene silencing, these results uncover a sophisticated regulatory axis that governs specialized metabolism. Furthermore, this work expands the known functional scope of the evolutionarily conserved miR160-ARF module beyond its traditional role in plant architecture and auxin signaling, repositioning it as a central component of secondary metabolic regulation. These findings provide a theoretical foundation and a robust molecular target for the metabolic engineering and genetic improvement of P. notoginseng quality.
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openalex_W7207749914 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wenqing Li, Chunyu Liu, Yuan Qu, Diqiu Liu, Feng Ge
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Journal Plant physiology and biochemistry : PPB
Year 2026
DOI
10.1093/plphys/kiag656
URL
https://doi.org/10.1093/plphys/kiag656
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