Emerging Paradigms in Glycobiology

Clicks: 9
ID: 327465
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #38 of 51 articles by views in glycobiology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Modern glycobiology is a result of multiple revolutionary and ground-breaking observations that both challenged and eventually changed prior perspectives about the expression and biological roles of glycoconjugates. These sweeping transformations in the field altered concepts that were embedded in what may be termed paradigms. Some prior paradigms included ideas that are still echoed in the current scientific literature, such as glycosylation of proteins is only found on secreted and membrane-associated proteins; glycans do not have clear and specific functions; protein binding to carbohydrates is relatively low affinity and non-specific; and protein glycosylation is relatively random and highly heterogeneous. As prior paradigms reached a crisis in terms of their supportability, they were replaced by new paradigms. The number of such new paradigms is large and documenting them is important. These modern paradigms include the idea that wide-spread modifications of amino acids with different sugars are common, that specific protein glycosylation occurs, the presence of glycoproteins in all cellular compartments, numerous roles of glycans and genes encoding their synthesis in human diseases, and the nature of carbohydrate recognition beyond simple sugars, and many others. Many researchers may not be aware of these emerging paradigms that have been developing in the research community since the 1960s. Here we summarize these new paradigms and some are discussed in detail from an historical perspective. These new paradigms demonstrate the essentiality and novelty of glycans and their biological functions.
Reference Key
openalex_W7207674698 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Richard D. Cummings
Journal glycobiology
Year 2026
DOI
10.1093/glycob/cwag077
URL
https://doi.org/10.1093/glycob/cwag077
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.