A Ten-Year Retrospective Study on the Clinical and Microbiological Characteristics of Early Onset Neonatal Sepsis at a Single Tertiary Care Institution

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ID: 327362
2026
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Abstract
Abstract Background Early-onset neonatal sepsis remains a significant cause of morbidity and mortality globally. Although Group B Streptococcus and Escherichia coli were commonly known to be the most common causes of Early-onset neonatal sepsis, this can vary per institution, thus creating a challenge in management. Understanding the clinical and microbiological profile of neonatal sepsis in a single-center study is crucial to improving diagnosis and treatment, strategies. Objectives This study aimed to characterize demographic, clinical, and microbiological features of neonates with early-onset neonatal sepsis, evaluate antimicrobial susceptibility patterns, and assess temporal trends and clinical outcomes over a ten-year period from 2015 to 2024. Methods A retrospective cohort study at a private tertiary hospital included 409 neonates with Early-onset neonatal sepsis. Data on demographics, clinical features, maternal and perinatal risk factors, laboratory results, microbiological findings, antimicrobial susceptibility, and outcomes were collected. Annual trends in culture-positive versus culture-negative cases were analyzed. Statistical tests, including chi-square and t-tests, were utilized. Results Culture-positive neonates had significantly lower birthweight and gestational age, with tachypnea and temperature instability as common signs. The culture-negative group had more asymptomatic cases (20.8% vs 6.3%). Premature rupture of membranes remains the most frequent risk factor. Methicillin-resistant Staphylococcus epidermidis predominated, differing from typical pathogens like Group B Streptococcus. C-reactive protein better distinguished culture-positive sepsis, while leukopenia rather than leukocytosis was a key Complete Blood Count indicator for sepsis. Gram-positive isolates showed high resistance to beta-lactams but remained susceptible to vancomycin and linezolid. Gram-negative isolates were highly susceptible to Amikacin and Piperacillin-tazobactam. Culture-positive sepsis carried a higher mortality (4.2%). Temporal analysis did not exhibit a significant secular trend over the study period. Conclusion Early-onset Neonatal sepsis in this population is marked by vulnerability related to prematurity and low birthweight, diverse clinical presentations, and multidrug-resistant pathogens. Integrated surveillance, tailored antimicrobial stewardship, and targeted preventive strategies are crucial for reducing the sepsis burden and improving neonatal outcomes.
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Authors Vilma Antonette B Prado, Amanda Louise Du
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Journal journal of the pediatric infectious diseases society
Year 2026
DOI
10.1093/jpids/piag070/piag070.036
URL
https://academic.oup.com/jpids/article-pdf/15/Supplement_2/S16/70833230/piag070.036.pdf
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