The transcription factor CLAMP is required for neurogenesis in Drosophila melanogaster

Clicks: 4
ID: 327343
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #323 of 329 articles by views in current genetics

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 329 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Neural stem cell (NSC) differentiation is controlled by cell-intrinsic and external signals from the stem cell niche including niche surface glia (SG). However, the mechanisms by which transcription factors drive NSC differentiation within the niche remain largely unknown. Here, we show that the Drosophila melanogaster transcription factor Chromatin-linked adaptor for MSL proteins (CLAMP) is required for regulation of stemness and proliferation of NSCs, especially in the optic lobe (OL). Using a validated clamp null mutant, we show that CLAMP promotes transcription of genes involved in stemness, proliferation, and glial development and represses transcription of genes involved in neurogenesis and niche survival. Consistent with transcriptional changes, CLAMP promotes NSC proliferation and niche SG production, while lack of CLAMP severely and specifically impacts OL development. To identify potential mechanisms by which CLAMP may regulate brain development, we examined CLAMP binding site motifs and available CLAMP ChIP-seq data to determine which genes may be direct versus indirect targets. We found that genes encoding Notch and tailless, both master regulators of brain development, are directly bound by CLAMP, indicating that they are key direct targets of CLAMP. Moreover, Notch and Tailless are critical for OL development, providing a mechanistic link to the severe deficits observed in OL development in the clamp null mutants. Overall, our results suggest that CLAMP regulates a core transcriptional program which drives NSC proliferation and differentiation via cell-intrinsic and niche-dependent mechanisms involving niche glia and transcriptional regulation of Notch and Tailless.
Reference Key
openalex_W7204656243 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Maria A. Tsiarli, James Kentro, Ashley Mae Conard, Lucy Xu, Erica Nguyen, Erica Larschan
Journal current genetics
Year 2026
DOI
10.1093/genetics/iyag229
URL
https://doi.org/10.1093/genetics/iyag229
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.