Outbreak of Ralstonia spp. Central Line-Associated Bloodstream Infections in Pediatric Intensive Care Units, Peru 2025

Clicks: 13
ID: 327295
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #109 of 147 articles by views in journal of the pediatric infectious diseases society

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 147 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Ralstonia spp. is an opportunistic Gram-negative bacilli. It can persist in aqueous environments and medical devices, posing risks for nosocomial outbreaks, particularly in immunocompromised patients. We describe an outbreak of central line-associated bloodstream infections (CLABSIs) caused by two Ralstonia species related to contaminated dexmedetomidine ampoules. Methods A descriptive study was conducted at a pediatric tertiary care center specializing in oncology, surgery, and transplantation. The outbreak spanned July 19 to August 23, 2025, affecting the Cardiovascular, Pediatric, and Burn Intensive Care Units (ICUs). Microbiological identification utilized Matrix-Assisted Laser Desorption/Ionization–Time of Flight. Whole-genome sequencing assessed clonality and phylogenetic relationships with prior published outbreaks. Hospital epidemiology teams conducted environmental sampling and implemented infection control measures to identify and mitigate the outbreak source. Results Twelve CLABSI cases were identified, comprising 11 R. pickettii and one R. flatus infections. Most (75%) occurred in the Cardiovascular ICU, predominantly among patients with congenital heart disease (67%). The median patient age was 9.5 months (interquartile range: 3 months to 2 years). Fever was the most common presenting symptom (41.7%). Phenotypically, 8.3% of isolates exhibited carbapenem resistance. The fatality rate was 25% and the attack rate was 32%. Genomic sequencing confirmed clonality of R. pickettii (rST-37889) and identified phylogenetic proximity to 2023 outbreaks in Germany and Australia. R. pickettii harbored intrinsic resistance genes (blaOXA-60, blaOXA-22) and efflux pump genes (adeF, vanH). R. flatus (rST-170880) carried blaOXA-60, blaOXA-899, adeF, and vanH. The outbreak was controlled by stopping the usage of dexmedetomidine ampoules belonging to the same manufacturing batch. Conclusion This outbreak of CLABSIs caused by R. pickettii and R. flatus due to contaminated dexmedetomidine ampoules in a pediatric tertiary care center underscores the challenges of managing nosocomial infections by emerging pathogens. Molecular surveillance was pivotal in confirming clonality and international linkages. These findings highlight the importance of strengthening drug supply chain oversight and establishing robust genomic surveillance systems to mitigate the risks posed by nosocomial pathogens.
Reference Key
openalex_W7204636059 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Medalit Luna Vílchez, Mitsi Lorraine Santiago Abal, Humania Aguirre Chávez, Claudia Cristel Marroquín Gálvez, Rosario Inés Huasapoma Ortega, Pool Flores, Jorge Osada, Jorge L Salinas
Are you one of these authors? Claim your profile
Journal journal of the pediatric infectious diseases society
Year 2026
DOI
10.1093/jpids/piag070/piag070.047
URL
https://academic.oup.com/jpids/article-pdf/15/Supplement_2/S20/70833315/piag070.047.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.