Continuous glucose monitoring to track metabolic changes in youths with cystic fibrosis before and after initiation of elexacaftor/tezacaftor/ivacaftor therapy

Clicks: 22
ID: 327125
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #134 of 449 articles by views in the journal of clinical endocrinology & metabolism

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 449 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
INTRODUCTION: Glucose tolerance abnormalities can be detected in preschool and school-age children with cystic fibrosis. There is limited data on the impact of CFTR modulator elexacaftor/tezacaftor/ivacaftor (ETI) on their trajectories. We examined CGM metrics before and after ETI initiation across different pediatric age groups. METHODS: We included participants from the French MODUL-CF real world study aged 2-18 years with at least 24 hours of CGM data before initiation of ETI and a 2nd CGM 12±3 months following ETI start. The cohort was stratified in 3 groups based on the age at ETI initiation: <6, 6-12 and >12 years. CGM derived glucose metrics were compared before and after ETI. RESULTS: 98 patients with CF were enrolled, including 13 preschool children, 55 school age children and 32 adolescents. At baseline, participants displayed a time in tight glucose range (TITR) of 89.8%(84.1, 93.4) with 34% of the whole cohort spending >10% of time>140mg/dL (TA140). Following treatment, TITR increased of ∼2%(+1.8[-1.8, +6.0]%) (p=0.004). This was associated with a 0.4% reduction of mild-hyperglycemia (>140mg/dL) and a lower CV (21.5%(19.0, 24.7) vs 19.6%(17.0, 22.6), p<0.001). Those with TA140≤10% at baseline displayed greater weight gain and improvement of lung function respect to the group with TA140>10%. CONCLUSION: ETI is associated with improvement of CGM glucose in children and adolescents with CF. TA140 before ETI initiation may impact the trajectory of clinically relevant outcomes.
Reference Key
openalex_W7204779225 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alfonso Galderisi, Hadija Marchiori, Laurence Weiss, Alix Besançon, Nathalie Stremler, A. Lustre, D. Sahki, Anne-Marie Bonnel, Isabelle Sermet‐Gaudelus, the Modul-Cf group, Marianne Alison, Baptiste Arnouat, Melissande Baravalle, Mahassen Barboura, Jeanne Barillon, Audrey Barzic, Lilia Benhalla, Myriam Benhamida, Khadidja Bennour, Laureline Berteloot, Katia Bessaci, Antoine Bessou, M. Biard, Thiphaine Bihouée, Aurore Blondé, Nesrine Bouleghlem, Bertrand Bruneau, S. Bui, Aline Carsin-Vu, Mathilde Casson-Masselin, Justine Chanclud, F. Chedevergne, Camille Cisterne, Harriet Corvol, Laure Cosson, L. Couderc, Carole Couette, Marie‐Laure Dalphin, P. De Carli, Eric Deneuville, Gael Dournes, Valerie Douzal, Hubert Ducou-le-Pointe, Clémence Dufour-Barba, Raphael Enaud, Mathilde Ferry, Morgane Floch, P. Foucaud, Flaviu Gabor, Asma Gabsi, Elsa Gachelin, Charlotte Giraud, Fatiha Hassani, Audrey Herzog, Véronique Houdouin, Antoine Delval, Anne Houzel, F. Huet, Antoine Hutt, Ahmed Kheniche, Marie Jamin, K. Kaba, Sébastien Kiefer, Guillaume Labbé, Alice Ladaurade, J. Languepin, Muriel Laurans, Laurence Leclainche-Viala, Faustine Lefebvre, T. Lefrançois, Servane Lelez-Soquet, Marion Lenoir, Louis-Marie Lieber, C. Livrozet, Catthy Lléréna, Alexia Letierce, Damien Mandry, Sarah Marchal, Christophe Marguet, Sophie Mayer, Stéphane Mazur, Laurent Mély, Rania Messaoudi, Marie Mittaine, Baptiste Morel, Camille Ohlmann, J. Pengam, S Perrez, Caroline Perisson, Thomas Perrin, Isabelle Petit, Philippe Petit, Juliette Pezron, C. Piccini-Bailly, Delphine Pouradier, Cinthia Rames, A. Rega, Philippe Reix, Martine Remy
Are you one of these authors? Claim your profile
Journal the journal of clinical endocrinology & metabolism
Year 2026
DOI
10.1210/clinem/dgag358
URL
https://doi.org/10.1210/clinem/dgag358
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.