The Impact of Respiratory Syncytial Virus Undertesting on Estimates of Disease Burden and Vaccine Effectiveness in a Large Integrated Healthcare System

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ID: 326944
2026
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Abstract
Abstract Infrequent standard-of-care (SOC) testing for respiratory syncytial virus (RSV) in adults with acute respiratory illness (ARI) contributes to underestimated disease burden. We compared RSV prevalence and RSV vaccine effectiveness (VE) among 14,044 adults ≥60 years with ARI ED/hospital admissions receiving SOC RSV testing versus those with SOC or salvaged respiratory specimen RSV testing. RSV was identified in 139 (0.99%) specimens by SOC testing alone versus 483 (3.44%) via SOC combined with salvage testing. Precision of VE against RSV-related ARI ED/hospital admissions improved substantially with inclusion of salvage testing compared to SOC testing alone (92% [67%- 98%] vs 90% [29%- 99%]).
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Authors Bradley K. Ackerson, Brandon Chia, Negar Aliabadi, Gabriella Goodwin, Jeff Slezak, Vennis Hong, Qing Liu, Sally F. Shaw, Sabrina Welsh, Julie Stern, Banshri Kapadia, Brigitte Spence, Joseph A Lewnard, Gregg Davis, Evan J Zasowski, Michael Aragones, Ashley Miller, Michael Dutro, Erica Chilson, Elisa Gonzalez, Robin Hubler, Luis Jódar, Bradford D Gessner, Elizabeth Begier, Sara Y. Tartof
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Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag572
URL
https://doi.org/10.1093/ofid/ofag572
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