Zero-Fluoroscopy, ICE-Only Patent Foramen Ovale Closure in Early Pregnancy: A case report

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ID: 326911
2026
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Abstract
Abstract Background Transcatheter closure of a patent foramen ovale (PFO) is an established strategy for secondary prevention of cryptogenic stroke in selected patients. During pregnancy, the timing and method of closure require individualized assessment of recurrent embolic risk and maternal–fetal procedural risk. In selected first-trimester patients, avoiding fluoroscopy, contrast, procedural transoesophageal echocardiography (TEE), and sedation may be desirable when adequate alternative imaging is available. Case summary A 34-year-old woman at 7 weeks’ gestation presented with acute ischaemic stroke. Work-up demonstrated a non-lacunar cortical infarct, long-tunnel PFO with a large provoked right-to-left shunt, and no alternative embolic source; the Risk of Paradoxical Embolism score was 9. After multidisciplinary discussion, early percutaneous closure was performed using a completely zero-fluoroscopy, intracardiac echocardiography (ICE)-only workflow under local anaesthesia, without procedural TEE. Key adaptations included use of a pre-shaped transseptal sheath for stable cannulation and a left atrial rail using a pre-shaped support wire. Stop-flow balloon sizing was performed and agitated saline was injected through the delivery sheath as an adjunctive visual check of left atrial position prior to device release. A 25/18-mm Amplatzer Talisman PFO occluder was deployed successfully with no complications. Discussion This case demonstrates the feasibility of zero-fluoroscopy, zero-contrast PFO closure under ICE-only guidance in a carefully selected first-trimester pregnant patient. The combination of stable sheath engagement, a pre-shaped left atrial support-wire rail, stop-flow balloon sizing, and sheath-through agitated saline injection facilitated controlled device deployment without fluoroscopy or contrast. This approach depends on operator expertise and institutional familiarity with ICE-guided structural intervention.
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Authors Soo Hyun Jo, Tae‐Hoon Kim, Yong‐Joon Lee, Kyeong Ho Yun, Jung‐Sun Kim
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Journal European Heart Journal - Case Reports
Year 2026
DOI
10.1093/ehjcr/ytag635
URL
https://doi.org/10.1093/ehjcr/ytag635
Keywords Keywords not found

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