Temporal Histological Tissue Responses Following Fractional Non-Ablative 1470 nm Laser Exposure: A Pilot In Vivo Human Study

Clicks: 43
ID: 326888
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #3 of 125 articles by views in Aesthetic Surgery Journal Open Forum

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 125 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Fractional non-ablative lasers enable controlled dermal heating while preserving epidermal integrity. The 1470 nm wavelength shows strong water absorption and moderate penetration, but in vivo human histological data on early tissue responses remain limited. Objectives To characterize early, time-dependent histological responses and assess short-term histologic tolerability of a fractional 1470 nm laser (LaserMe). Methods Eighteen healthy adults were enrolled and allocated to six treatment groups according to energy setting and spot spacing. For the present analysis, only samples treated at 28 and 50 mJ/point were included, as the 5 mJ/point setting produced no measurable histological response. Clinical assessment and full-thickness skin biopsies were performed at baseline, immediately after treatment, and on days 3 and 10. Histology was evaluated using hematoxylin–eosin and Masson’s trichrome staining. Results Treatment produced spatially confined micro-injury zones with preservation of surrounding tissue. Immediately post-treatment, localized changes were observed at the dermal–epidermal junction with minimal epidermal involvement. By day 3, re-epithelialization and basement membrane restoration were evident. By day 10, epidermal continuity was fully restored, with reduced dermal thermal alteration and mild inflammatory infiltrates consistent with reparative processes. Higher energy increased dermal penetration without extending superficial epidermal damage. Conclusions Fractional 1470 nm laser exposure induces a predictable, localized histological response consistent with possible early tissue remodelling and suggests favorable short-term histologic tolerability in healthy adult skin. This exploratory preliminary report provides mechanistic insight into non-ablative laser–tissue interactions and was not designed to assess clinical efficacy or long-term safety.
Reference Key
openalex_W7204929902 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Paweł Kubik, Wojciech Gruszczyński, Aleksandra Pawłowska, Maciej Malinowski, Maria‐Luiza Piesiaków, Brygida Baran, Agnieszka Pawłowska-Kubik, Łukasz Kodłubański, Dariusz Grzanka, Paulina Antosik, Bartłomiej Łukasik
Are you one of these authors? Claim your profile
Journal Aesthetic Surgery Journal Open Forum
Year 2026
DOI
10.1093/asjof/ojag161
URL
https://academic.oup.com/asjopenforum/advance-article-pdf/doi/10.1093/asjof/ojag161/70896063/ojag161.pdf
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.