Human metapneumovirus-associated hospitalisation burden in children aged under 5 years in Scotland between 2017 and 2023: a retrospective analysis

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2026
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Abstract
Abstract Background Human metapneumovirus (hMPV) is commonly associated with respiratory tract infections (RTIs) in young children. Methods We estimated the annual hospital incidence of hMPV RTIs in children under 5 years in Scotland from 2017 to 2023 using national hospital and laboratory data. Incidence outside Lothian, where testing practices were uncertain, was extrapolated from Lothian laboratory data, where hMPV testing was advised for all RTI admissions. We also examined the severity and mortality of laboratory-confirmed hMPV cases. We developed similar estimates for RSV and Influenza A for comparison. Results This analysis included 1,462 laboratory-confirmed hMPV hospitalisations in children aged under 5 years. The extrapolated hMPV hospital incidence ranged from 19 per 100,000 to 537 per 100,000 in children aged under 5 years. The extrapolated incidence was two to three times higher than that based on laboratory-confirmed data. Hospital incidence was higher in infants than in toddlers. hMPV incidence dropped substantially during the 2020/21 season, followed by a rebound during the 2021/22 season. About 10% of hMPV RTI hospital admissions required hospital stay ≥5 days, but <1% required intensive care unit admissions or resulted in in-hospital death. RSV hospital incidence appeared substantially higher than the hMPV hospital incidence in this population. Conclusions hMPV RTIs contribute to a substantial hospital burden in young children in Scotland. However, the RSV RTI burden is likely to be higher in the population unvaccinated against both viruses. Improved surveillance and diagnosis strategies are required to develop robust hospital burden estimates. Summary Human metapneumovirus was associated with substantial hospitalisations in children under 5 years, particularly infants, in Scotland between 2017 and 2023. Incidence peaked in 2021/22 after a sharp decline in 2020/21. Most admissions were brief, with few requiring intensive care or resulting in death.
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Authors Durga Kulkarni, Richard Osei‐Yeboah, Kate Templeton, Harish Nair
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Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag532
URL
https://doi.org/10.1093/ofid/ofag532
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