Tumor-to-tumor metastasis: a rare case of clear cell renal cell carcinoma metastasizing into lung adenocarcinoma

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ID: 326609
2026
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Ranked #79 of 147 articles by views in Interdisciplinary CardioVascular and Thoracic Surgery

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Abstract
Tumor-to-tumor metastasis (TTM) is a very rare condition in which a malignant tumor (donor) metastasizes into another primary neoplasm, either benign or malignant (recipient). We report the case of a 74-year-old man previously surgically treated for a clear cell renal cell carcinoma(ccRCC) who developped a new subsolid nodule in the right upper pulmonary lobe discovered at a four-year follow-up CT scan. The patient underwent a right uniportal thoracoscopic S1 segmentectomy and mediastinal lymph node dissection. Histopathological examination revealed a lung adenocarcinoma (LUAD) containing a focus of metastatic ccRCC without lymph node involvement or evidence of additional metastatic disease. To date, the patient remains disease-free. Metastasis of renal tumor cells into a primary lung tumor is exceptionally rare. To our knowledge, this is the first reported case of ccRCC metastasizing into LUAD without evidence of systemic dissemination.
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openalex_W7204567266 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors
Journal Interdisciplinary CardioVascular and Thoracic Surgery
Year 2026
DOI
10.1093/icvts/ivag201
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