Association of Early Postoperative MRI-Based RANO-Resect With Survival in WHO 2021-Defined IDH-Mutant High-Grade Gliomas

Clicks: 22
ID: 326533
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #19 of 65 articles by views in Neuro-Oncology Practice

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Direct evidence for postoperative residual-burden stratification remains limited in WHO 2021-defined isocitrate dehydrogenase (IDH)-mutant high-grade gliomas. We evaluated whether early postoperative MRI-based Response Assessment in Neuro-Oncology resect (RANO-resect) was associated with overall survival (OS) and progression-free survival (PFS). Methods This single-center retrospective cohort study screened consecutive patients undergoing first resection for newly diagnosed diffuse glioma between May 1, 2018 and May 1, 2024. Eligibility required preoperative MRI, early postoperative MRI within 72 hours, segmentable contrast-enhancing and non-enhancing tumor data, and follow-up. Results Fifty-nine patients were enrolled; 58 formed the final analytic cohort after exclusion of 1 RANO-resect class 1 patient. Four-group Kaplan-Meier analyses were significant for OS (log-rank P = 0.003) and PFS (log-rank P < 0.001). In the prespecified multivariable Cox model adjusted for age, sex, CNS WHO grade, and tumor type, each 1-class increase in RANO-resect was associated with worse OS (hazard ratio, 1.68; 95% confidence interval, 1.10-2.57; P = 0.016) and PFS (hazard ratio, 1.36; 95% confidence interval, 1.01-1.82; P = 0.040). Extended models that added preoperative imaging covariates one at a time showed directionally consistent RANO-resect estimates. Conclusions Higher early postoperative MRI-based RANO-resect class was associated with worse survival in WHO 2021-defined IDH-mutant high-grade gliomas, with the most consistent signal for OS. RANO-resect may support standardized postoperative residual-burden stratification but should be interpreted alongside baseline tumor burden and should not guide treatment decisions alone.
Reference Key
openalex_W7204260351 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guiliang Liu, Juan Liu, Qian Li, Qianzi Xue, Mulin Xie, Xunxun Wang, Yu Cai, Zhong Deng, Shuwen Yang, Xiaoyan Zhang, Rui He, Weiyu Liu, Xuzhe Zhao, Xinliang Wang
Are you one of these authors? Claim your profile
Journal Neuro-Oncology Practice
Year 2026
DOI
10.1093/nop/npag088
URL
https://doi.org/10.1093/nop/npag088
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.