Autoimmune Hepatitis in Two Patients with Behçet’s Disease: A Case Report

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ID: 326372
2026
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Abstract
Abstract Background Behçet’s disease (BD) is a multisystem inflammatory disorder with variable manifestations. Although hepatic involvement is rare, abnormal liver enzymes may occasionally be observed. We describe two patients with BD who developed autoimmune hepatitis (AIH), confirmed by liver biopsy. Case Presentation We report two Iranian patients—one male and one female—diagnosed with BD, who later developed persistently elevated liver enzymes. Both had elevated IgG levels, negative viral hepatitis markers, and liver biopsy findings compatible with autoimmune hepatitis (AIH). Due to limited retrospective serologic data, the diagnosis was established based on multidisciplinary clinicopathological assessment and response to immunosuppressive therapy. Sonography showed fatty liver in both cases. Treatment with azathioprine and prednisolone led to normalization of liver enzymes over a long-term follow-up. Conclusions Although uncommon, AIH can co-occur with BD and should be considered in patients with persistently elevated transaminases. Liver biopsy is crucial for definitive diagnosis. Early immunosuppressive therapy can prevent disease progression.
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Authors Majid Alikhani, Seyed Mohammad Tavangar, Mina Nikvarz, Somayeh Soroureddin
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Journal Modern Rheumatology Case Reports
Year 2026
DOI
10.1093/mrcr/rxag062
URL
https://doi.org/10.1093/mrcr/rxag062
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