Menopausal Transition and Thyroid Function Trajectories: A Large-Scale Longitudinal Study of Healthy Women
Clicks: 1
ID: 325625
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #358 of 359 articles by views in the journal of clinical endocrinology & metabolism
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 359 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
CONTEXT: Thyroid dysfunction and menopause both affect cardiovascular risk, but the specific influence of the menopausal transition on thyroid function independent of aging remains unclear. OBJECTIVE: To examine longitudinal changes in thyroid function across the menopausal transition among a large cohort of healthy midlife women. DESIGN: Longitudinal cohort study (2004-2024) using annual health checkup data and interrupted time-series analyses within mixed-effects linear models. SETTING: Annual health screening program at St. Luke's International Hospital, Tokyo, Japan. PARTICIPANTS: 7,644 Japanese women who experienced natural menopause and had at least one health checkup both before and after menopause. Those with hormone therapy or surgical menopause were excluded. MAIN OUTCOME MEASURES: Serum TSH and free thyroxine (fT4) levels. Secondary outcomes included abnormal TSH categories (>4.5, >10.0, <0.4, and <0.1 mIU/L) and self-reported thyroid disorders. RESULTS: Over a median 13.7-year follow-up (86,967 visits), TSH increased by 0.014 mIU/L per year (95% CI, 0.010 to 0.019) before menopause, with no significant slope change at menopause (additional change, -0.006 mIU/L per year [CI, -0.012 to 0.000]). fT4 levels decreased by 0.005 ng/dL per year (CI, -0.006 to -0.005) before menopause and stabilized thereafter (additional slope change, +0.005 ng/dL per year [CI, 0.004 to 0.005]). The prevalence of abnormal TSH and thyroid disorders increased with age, but there were no distinct changes at menopause. CONCLUSIONS: Menopause was not associated with clinically meaningful changes in thyroid function beyond aging. Age-related factors, rather than the menopausal transition, may largely explain increasing thyroid abnormalities in midlife women.
| Reference Key |
openalex_W7203787569
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Seiko Hayashi, Sho Fukui, Angela M. Leung, Hiroshi Noto, Kosuke Inoue |
| Journal | the journal of clinical endocrinology & metabolism |
| Year | 2026 |
| DOI |
10.1210/clinem/dgag337
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.