Lenacapavir use in France: a national, observational study (LENAddOn)

Clicks: 9
ID: 325593
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #46 of 208 articles by views in Open forum infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 208 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Context The LENAddOn study aimed to: characterize PWH initiating injectable lenacapavir (LEN) post-early access program in France; assess LEN continuation rates at W26 and W52; describe reasons for LEN discontinuation. Methods Observational, retrospective study across 19 centers, including people with HIV-1 who initiated LEN between 20/06/2023 and 30/06/2024. Socio-demographic, clinical, and laboratory data were extracted from medical records. The primary outcome was the proportion of PWH receiving a second and third set of LEN injections at W26 and W52. Results 77 PWH were included (median age 57 years [IQR 44-63]; duration of ART 25 years [17-29]), with a history of frequent adherence issues and vulnerability factors. At LEN initiation, 22 (28.6%) had a plasma HIV-1 viral load (pVL) ≥200 copies/mL and 43 (55.8%) a pVL <50 copies/mL; 42 (54.6%) had viral resistance to ≥2 drugs in ≥3 classes. 21 participants (27.3%) received injectable ART associating LEN plus cabotegravir ± rilpivirine. LEN continuation rate was 94.8% (95% CI 87.2-98.6) at W26, and 81.8% (71.4-89.7) at W52, with 4 LEN discontinuations between D0 and W26, and 10 between W26 and W52. Main reasons for LEN discontinuation were: death unrelated to LEN/lost-to-follow-up (n=5), persistence of viral replication (n=3) and injection site reactions (ISRs, n=2). Last measured pVL during the study period was <200 cp/mL in 72/77 participants (93.5%), and <50 cp/mL in 61/77 (79.2%). Conclusion LEN use allowed simplification of antiretroviral regimens, with the maintenance or achievement of virological suppression. Continuation of LEN at W26 and W52 remained high among a population with extensive treatment history.
Reference Key
openalex_W7203792536 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jade Ghosn, Valérie Pourcher, Clotilde Allavena, Laurent Hocqueloux, Karine Lacombe, Éric Cua, Fabrice Bonnet, Claudine Duvivier, Alain Makinson, Christine Jacomet, C. Lascoux, Jean‐Paul Viard, Olivier Robineau, Maxime Hentzien, Elina Teicher, Gilles Pialoux, Sophie Abgrall, Charles Cazanave, André Cabie, Yasmine Dudoit, Gilles Peytavin, Guillaume Barriere, Keith Dunn, Anne‐Geneviève Marcelin, L. Assoumou, Romain Palich, for the LENAddOn Study Group, Charles Cazanave, Pauline Perreau, Tanguy Vincent, Fabrice Bonnet, J. Delaune, Camille Krzyzanowsky, Sophie Abgrall, Agnès Cros, Laurent Richier, Alain Makinson, Corinne Merle, Célia Bouhnik, Laurent Hocqueloux, Barbara De Dieuleveult, Cécile Goujard, Yann Quertainmont, Sandrine Poirier, Elina Teicher, V Godard, Jade Ghosn, Caroline Proux, Antoine Bachelard, Zélie Julia, Racha Ibrahim, Awa Ndiaye, André Cabie, Ornella Cabras, Lorry Facelina, Firouzé Bani‐Sadr, Maxime Hentzien, Yohan N’Guyen, I Kmiec, Jean‐Paul Viard, Wiem Loghmari, V. Le Baut, Clotilde Allavena, Morane Cavallec, Soria Albane, Ernesto Paredes Manyari, Éric Cua, S Bréaud, Iris Touitou, Gilles Pialoux, Martin Siguier, Christia Palacios, Mouniya Mebarki, Anne Adda-Lievin, Christine Jacomet, Dilek Çoban, Olivier Robineau, V. Baclet, Pauline Cornavin, Nathalie Viget, Marie-Christine Marien, Claudine Duvivier, Carole Louisin, Elisabete Gomes Pires, Jean‐Michel Molina, C. Lascoux, Nadia Laradh, Karine Lacombe, Zineb Ouazene, Christian Tran, Rania Zemouri, Julie Lamarque, Ikrame Benyamina, Marc‐Antoine Valantin, Afiya Nadour, Naïma Hamani, M Chansombat
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag512
URL
https://doi.org/10.1093/ofid/ofag512
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.