The Link Between Acromegaly, Liver Morphology, and MASLD: A Large Cohort Analysis
Clicks: 2
ID: 325498
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
0.3
/100
2 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #65 of 91 articles by views in european journal of endocrinology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
OBJECTIVE: To evaluate liver morphology and clinical determinants in acromegaly. DESIGN: Retrospective single-center cohort study. METHODS: We analyzed 394 acromegaly patients followed at a single tertiary center over four decades for hepatic morphology and metabolic dysfunction-associated steatotic liver disease (MASLD). Patients were compared by hepatic cyst and MASLD status; multivariable logistic regression identified independent predictors, using outcome-specific primary hormonal exposures-the peri-imaging IGF1×ULN for MASLD and time-weighted-average IGF1×ULN (TWAvg) for hepatic cysts. Standardized prevalence ratios (SPR) against age- and sex-stratified references were also examined. RESULTS: Of 282 imaged patients, MASLD, hepatic cyst, hemangioma, and cholelithiasis prevalence was 31.0%, 15.6%, 4.3%, and 36.8%. Cyst prevalence matched population estimates, whereas imaging-detected MASLD was significantly lower than expected (SPR 0.56-0.78). Hepatic cyst was independently associated with renal cyst (OR 2.769) and inversely with MASLD (0.231), with older age borderline significant. MASLD was inversely associated with the peri-imaging IGF1×ULN (OR 0.74 per doubling), hepatic cyst (0.109), and longitudinal exposure (log2 TWAvg IGF1×ULN 0.61), and positively with cholelithiasis (3.158). CONCLUSIONS: Hepatic cyst prevalence matched population estimates, whereas imaging-detected MASLD was significantly lower. Cysts associated with older age, renal cysts, and absence of MASLD; MASLD associated inversely with the peri-imaging and longitudinal IGF1 exposure and positively with cholelithiasis. The inverse cyst-MASLD relationship is hypothesis-generating: MASLD tracked GH/IGF1 activity whereas cysts did not, suggesting distinct hepatic phenotypes of a shared, as-yet-unmeasured determinant rather than opposite readouts of one hormonal signal.
| Reference Key |
openalex_W7203741561
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Polat Ercan, Büşra Fırlatan Yazgan, Süleyman Nahit Şendur, Selçuk Dağdelen, Tomris Erbaş |
| Journal | european journal of endocrinology |
| Year | 2026 |
| DOI |
10.1093/ejendo/lvag159
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.