PSMA PET/CT for Radiation Planning and Response Assessment in Intracranial High-Grade Gliomas

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ID: 325317
2026
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Ranked #98 of 105 articles by views in Neuro-Oncology Advances

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Abstract
Lay Summary Glioblastoma is an aggressive brain cancer, and it can be difficult to tell whether changes seen on scans after radiation treatment represent tumor growth or treatment-related effects. The authors of this study wanted to evaluate whether a specialized imaging test called PSMA PET could help define tumor boundaries for radiation planning and distinguish tumor progression from treatment-related changes. To do this, they performed PSMA PET scans in 27 patients with high-grade gliomas, including patients undergoing radiation planning and patients being evaluated for possible tumor recurrence. They found that tumors showed higher PSMA PET signal than surrounding tissue, that PSMA PET sometimes identified tumor beyond what was visible on standard MRI, and that it correctly distinguished tumor progression from treatment-related changes in most patients.
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openalex_W7203671644 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rituraj Upadhyay, Pavnesh Kumar, Divya Yadav, Bingfeng Tang, Erika Bello‐Pardo, Hamid Mohtashami, Pawan Singh, Pierre Giglio, Kyle Wu, J Brad Elder, Sasha Beyer, Raj Singh, Raju R. Raval, Evan Thomas, Chi Zhang, Jana Ivanidze, Joshua D. Palmer
Journal Neuro-Oncology Advances
Year 2026
DOI
10.1093/noajnl/vdag217
URL
https://doi.org/10.1093/noajnl/vdag217
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