Tim-3 Upregulation in Monocyte Subsets as a Distinctive Immune Feature and Early Diagnostic Indicator in Systemic Lupus Erythematosus
Clicks: 1
ID: 325140
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #21 of 30 articles by views in Clinical & Experimental Immunology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
INTRODUCTION: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by immune dysregulation. Tim-3 is an immune checkpoint receptor implicated in various autoimmune conditions. This study aimed to evaluate Tim-3 expression across monocyte subsets in newly diagnosed, treatment-naive SLE patients and assess its clinical relevance and diagnostic potential. METHODS: Peripheral blood samples were analyzed using flow cytometry. Tim-3 expression and its co-expression with HLA-DR/DP/DQ, CD226, and CD62L were assessed. RESULTS: Results showed significantly elevated Tim-3 expression in all monocyte subsets in SLE patients compared to controls. Tim-3+ monocytes exhibited decreased VNN2 level, indicating an activated antigen-presenting phenotype. Upon LPS stimulation, Tim-3+ monocyte subsets secreted more TNF-α. The frequency of Tim-3+ monocytes positively correlated with anti-Ro52 and anti-SSA antibodies, negatively with C3 and IgM levels. ROC curve analysis demonstrated that Tim-3+ monocytes had moderate diagnostic performance for SLE, with area under the curve values of 0.7901. CONCLUSION: These findings suggest that Tim-3+ monocytes may serve as potential biomarkers for early SLE diagnosis.
| Reference Key |
openalex_W7203638638
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Yiming Gao, Qihui Han, Xiaoyi Zheng, Zhiwei Zong, Ziqi Xiong, Zhonghui Zhang, Ayibaota Bahabayi, Chen Liu |
| Journal | Clinical & Experimental Immunology |
| Year | 2026 |
| DOI |
10.1093/cei/uxag048
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.