Preferential Reservoir Seeding in HPV16-Specific CD4-T-Cells During HIV-1 Acute and Chronic Infection

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ID: 325069
2026
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Abstract
Abstract The anal canal represents the primary site of HIV-1 acquisition in men-who-have-sex-with-men (MSM), while MSM-living-with-HIV (MLWH) have the highest anal cancer incidence. Since HPV16-infection and low-nadir CD4-T-cell counts predict anal cancer risk, we developed an assay to identify and characterize HPV16-specific T-cell responses in MLWH. 40% of acutely and 81% of chronically infected MLWH had HPV16-specific CD4-T-cells, which harbored higher levels of HIV-1 DNA/RNA than non-HPV16-specific CD4-T-cells. T-cell-receptor (TCR) sequencing revealed a less diverse and more restricted TCR-repertoire in HPV16-specific CD4-T-cells. HPV16-specific CD4-T-cells represent an early-established preferential HIV-1 reservoir and a potential novel immunologic correlate of anal cancer-risk in MLWH.
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openalex_W7203473566 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Amay Shah, Carlo Sacdalan, Robert J. Gorelick, Derek MacMath, Christophe Vanpouille, Peiying Ye, Ginevra Bugani, Eugene Kroon, Suwanna Puttamaswin, Suteeraporn Pinyakorn, Alexandra Schuetz, Lydie Trautmann, Nittaya Phanuphak, Sandhya Vasan, Andrea Lisco
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Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag424
URL
https://doi.org/10.1093/infdis/jiag424
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