Population Pharmacokinetic Analysis of Factors Affecting the Clearance of Methotrexate Polyglutamates in Red Blood Cells in Japanese Patients with Rheumatoid Arthritis

Clicks: 10
ID: 324969
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #20 of 36 articles by views in modern rheumatology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Objectives To examine factors affecting the apparent clearance (CL/F) of total methotrexate polyglutamates (MTX-PGs) in red blood cells (RBCs) in Japanese patients with rheumatoid arthritis (RA) using population pharmacokinetic analysis. Methods A total of 268 Japanese RA patients receiving low-dose MTX therapy were included. RBC MTX-PGs concentrations were measured using LC–MS/MS. Patient characteristics, including genetic polymorphisms in transporters (RFC1, ABCB1, ABCC2, ABCG2) and enzymes (FPGS, GGH) related to MTX metabolism, were evaluated as covariates. Population pharmacokinetic analysis was performed using Phoenix NLME software. Results The final population pharmacokinetic model identified body weight (BW), estimated glomerular filtration rate (eGFR), and proton pump inhibitor (PPI) co-administration as covariates for CL/F of total RBC MTX-PGs. Lower BW, lower eGFR, and PPI use were associated with decreased CL/F. Genetic polymorphisms were not identified as significant covariates for CL/F in this study. Conclusions BW, eGFR, and PPI co-administration may influence the CL/F of total RBC MTX-PGs in Japanese patients with RA. These findings may support model-informed interpretation of RBC MTX-PGs concentrations, although further studies are needed to confirm the clinical applicability of the model.
Reference Key
openalex_W7202345391 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Jun Hakamata, Yuko Kaneko, Mikiko Shimizu, Tsutomu Takeuchi, Masayuki Hashiguchi
Journal modern rheumatology
Year 2026
DOI
10.1093/mr/roag063
URL
https://doi.org/10.1093/mr/roag063
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.