Anti-centromere antibody-positive primary Sjögren's disease with exudative pleural effusion: a case report and literature review

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ID: 324967
2026
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Abstract
Abstract Sjögren’s disease (SjD) is a systemic autoimmune disorder with glandular and extra-glandular manifestations. Pleural effusion is a rare complication of SjD among different types of pulmonary involvement. Herein, we report a case of primary anti-centromere (ACA)-positive primary SjD with pleural effusion. A 79-year-old woman was admitted to our hospital with a 3-month history of leg edema. She was diagnosed with primary SjD based on positive Schirmer and Saxon tests, and her anti-SS-A/Ro antibody test was negative but ACA and anti-SS-B/La tests were positive. The patient’s symptoms promptly improved following prednisolone treatment. This is the first reported case of ACA-positive primary SjD complicated with pleural effusion, and the possible presence of pleural effusion should be considered in SjD, even in patients with ACA-positive primary SjD.
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Authors Masashi Uchikawa, Masako Tsukamoto, Kiichi Sugito, Shinya Asatani, Masahiro Nishihara, Kumiko Akiya, Miho Oshima, Hirotake Inomata, Noboru Kitamura, Junki Kurita, Hiroyuki Hao, Hideki Nakamura
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Journal Modern Rheumatology Case Reports
Year 2026
DOI
10.1093/mrcr/rxag078
URL
https://doi.org/10.1093/mrcr/rxag078
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