Management, Outcomes, and Factors Associated with Mortality and Treatment Failure of Non- Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand
Clicks: 4
ID: 324965
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
4 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #83 of 207 articles by views in Open forum infectious diseases
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 207 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background Very few large regional studies have evaluated treatment responses and mortality across different non-Aspergillus mold infections. Methods We conducted a retrospective, 21-center, observational study of non-Aspergillus mold infections in Australia and New Zealand. Cases from 2016 to 2023 were identified from each hospital’s pathology system. Treatment modalities were evaluated, and outcomes (e.g. treatment response, mortality) were compared across non-Aspergillus mold infections at day 30, 90 and 180 follow-up. Multivariable analyses were performed to identify factors associated with 90-day mortality and treatment failure. Results Of 421 cases, 129 were Mucorales (30.6%), 89 Lomentospora prolificans (21.1%), 82 Scedosporium spp. (19.5%), 30 Fusarium spp. (7.1%), 44 other dematiaceous molds (10.5%), 27 other non-Aspergillus molds (6.4%), and 20 mixed non-Aspergillus mold infections (4.8%). Antifungal therapy was administered in 376 (89.3%), and 219 (52.0%) underwent adjunctive surgery. Among those who survived by day 180, 42.6% (n=115/270) remained on antifungals, with total duration exceeding 180 days. All-cause 90-day mortality was 31.4% (n=132/421), being the highest in Lomentospora prolificans infection (n=51/89, 57.3%). Neutropenia [hazard ratio (HR):2.19, 95% confidence interval (CI):1.30-3.69], intensive care unit admission (HR:2.51, 95%CI:1.60-3.92), disseminated infection (HR:2.55, 95%CI:1.59-4.10), Mucorales (HR:4.87, 95%CI:2.71-8.77) and L. prolificans infections (HR:3.71, 95%CI:1.97-6.98) were associated with increased 90-day mortality (all p<0.001). Adjunctive surgery was associated with a lower 90-day mortality (HR:0.34, 95%CI:0.21-0.54, p<0.001). Factors associated with 90-day treatment failure included neutropenia, prolonged corticosteroid use, solid cancer, disseminated infection, central nervous system infection, and L. prolificans infections (all p<0.05). Conclusions Despite antifungal therapy, L. prolificans infections had the poorest clinical outcomes followed by Mucorales, highlighting the need for improved diagnostic methods and therapeutic strategies.
| Reference Key |
openalex_W7202393987
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Chin Fen Neoh, Sharon C-A Chen, Arthur J. Morris, Christopher H. Heath, Shu Jin Tan, Rebekah Lane, Shio Yen Tio, Sze Yen Tay, Matthew B. Roberts, Karina Kennedy, Sebastiaan J. van Hal, Hugh Murray, Robert Pickles, Natasha Marcella Vaselli, Abby Douglas, Karen Urbancic, Mahesh Menon, Adam G. Stewart, Julia Howard, Caitlin Keighley, Spiros Miyakis, Rohan Beresford, Louise Cooley, Marjoree Sehu, Catriona Halliday, Sarah Kidd, David C M Kong, Tim Spelman, Leon J. Worth, Monica A. Slavin, the Australian and New Zealand Study Group for non-Aspergillus mold infections, Amy Crowe, Jane Davies, Michelle England, Dianne Gardam, Rupert Handy, M. Leitch, Catherine Marshall, Sarah Lynar, Owen Robinson, Philip Selby, Olivia Smibert, Peter Simos, Michelle K. Yong, Kar Yee Yong |
| Journal | Open forum infectious diseases |
| Year | 2026 |
| DOI |
10.1093/ofid/ofag474
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.