Systolic anterior motion of mitral valve leaflet following accessory pathway ablation in a patient without hypertrophic cardiomyopathy: a case report

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ID: 324931
2026
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Abstract
Abstract Background Accessory pathway ablation is recommended for patients with symptomatic Wolff–Parkinson–White (WPW) syndrome. Although elimination of the accessory pathway restores normal ventricular activation and improves synchrony, it can occasionally cause systolic anterior motion (SAM) of the mitral valve leaflet, which can lead to functional left ventricular outflow tract (LVOT) obstruction. Case Summary We report a case of a patient admitted with WPW syndrome. After successful posteroseptal accessory pathway ablation, the patient developed exertional chest tightness and syncope. Echocardiography revealed significant SAM of the mitral valve leaflet and an elevated LVOT peak pressure gradient. Cardiac magnetic resonance confirmed a sigmoid-shaped interventricular septum and a small left ventricular cavity. Genetic testing excluded pathogenic mutations in genes associated with hypertrophic cardiomyopathy. Treatment with metoprolol alleviated his symptoms, with no recurrence of syncope. Follow-up echocardiography showed that the SAM of the mitral valve leaflet had been resolved. Conclusion Although SAM of the mitral valve leaflet rarely occurs following accessory ablation, it could induce deleterious consequences. We hypothesized that the coexistence of a sigmoid septum and a small ventricular cavity may increase the risk for functional outflow tract obstruction after accessory pathway ablation.
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Authors Xuze Lin, Xixing Wang, Qiang Li, Fanqi Meng, Jinzan Cai
Journal European Heart Journal - Case Reports
Year 2026
DOI
10.1093/ehjcr/ytag605
URL
https://doi.org/10.1093/ehjcr/ytag605
Keywords Keywords not found

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