Pattern of Care and treatment outcome of high grade glioma patients at four Ethiopian teaching hospitals: A prospective cohort study

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ID: 324683
2026
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Abstract
Abstract Background High-grade gliomas are the most prevalent type of malignant brain tumor in adults & second leading cause of cancer-related death. This study assesses epidemiology, pattern of care & treatment outcome of high-grade glioma in Ethiopia. Methods A Prospective cohort study. Data collected was analyzed using SPSS. Frequency distribution was used to describe the characteristics of the study participants. Chi-squared tests and survival analysis were used to assess the treatment outcomes. Variables with p < 0.05 were considered as significant. Result There was a total of 40 patients. The median age at diagnosis was 47 years. Headache was the commonest presenting symptom (97.5%) followed by seizure (52.5%) and weakness (50%). The pre-operative tumor volume ranged between 3.9-168 cm3 with a mean volume of 80.38 cm3. 22 patients had ≥ 97% extent of resection. 17.5% of the patients died post treatment. The mean survival time was 20.77 months (95% CI: 18.46-23.09 months). There was significant association with higher Karnofsky performance status (KPS) scale (≥ 70), pre-operative GCS and post-operative adjuvant therapy with survival outcome (χ2= 10.19 P = 0.006, χ2= 12.9 P = 0.005, χ2= 6.716 P = 0.035) respectively. Conclusion In our study the mean survival time was 20.77 months. Higher KPS, pre-operative Glasgow coma scale (GCS) of 15 and patients receiving post-op adjuvant therapy had significant favorable association with survival in our study.
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openalex_W7202199542 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dawit Workneh Gechu, Tsegazeab Laeke Tekelemariam, Bethelhem Yesehak Worku, Mehari Wale Alem, Yordanose Girma Legesse
Journal Neuro-Oncology Advances
Year 2026
DOI
10.1093/noajnl/vdag207
URL
https://doi.org/10.1093/noajnl/vdag207
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