Resistant hypertension and epileptic seizures: a possible modulatory role of renal denervation – a case report
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ID: 324652
2026
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Abstract
Abstract Background Renal denervation (RDN) is an emerging therapy for selected patients with resistant hypertension. Its broader autonomic effects may extend beyond blood pressure regulation. Case summary A 57-year-old man with resistant hypertension treated with six antihypertensive drugs and recurrent autonomic and generalized seizures underwent radiofrequency RDN. At 3 months, ambulatory blood pressure monitoring (ABPM) showed sustained improvement (24 h mean 139/87 mmHg), enabling therapy de-escalation. Generalized tonic–clonic seizures resolved, and autonomic/focal events markedly decreased without changes in antiepileptic medication. Discussion This case illustrates a potential extrapressor effect of RDN mediated by modulation of sympathetic overactivity. Although causality cannot be drawn from a single case, the parallel neurological improvement supports exploring RDN’s role in conditions involving autonomic dysregulation, including certain epileptic syndromes.
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| Authors | Antonio Bustos-Merlo, Alberto Fajardo-Muñoz, Teresa Bretones del Pino, Eduardo Molina-Navarro, Fernando Jaén-Águila |
| Journal | European Heart Journal - Case Reports |
| Year | 2026 |
| DOI |
10.1093/ehjcr/ytag592
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| URL | |
| Keywords | Keywords not found |
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