Body mass index and major cardiovascular events after myocardial infarction: A nationwide registry study
Clicks: 5
ID: 323835
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
1.2
/100
5 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #89 of 196 articles by views in european journal of preventive cardiology
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 196 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
AIM: The "obesity paradox" suggests lower cardiovascular risk at higher body mass index (BMI) after myocardial infarction (MI), but whether it reflects true protection or methodological bias is unclear. METHODS: From the nationwide SWEDEHEART registry, patients hospitalised with MI from 2010-2021 were included. BMI at admission was modelled both as a continuous variable using restricted cubic splines and categorised into 6 groups, with 20 to <25 kg/m2 as reference. The primary outcome was major adverse cardiovascular events (MACE), a composite of recurrent MI, stroke, heart failure hospitalisation, or cardiovascular death. Cox regression models estimated the BMI associated with lowest risk and HRs for categorical BMI groups. Adjustments included sociodemographic factors, smoking, and comorbidities not attributed to obesity. Mediation analyses assessed the roles of diabetes, hypertension, and prior cardiovascular disease. RESULTS: In 173 617 patients, the mean age was 71.0 years, 66.7% were men, and mean BMI was 27.1 kg/m2. During a median follow-up of 3.3 years, 36.5% experienced MACE. BMI had a U-shaped association with MACE, with the lowest risk at BMI 25.1 kg/m2. The adjusted HR (95% CI) for MACE was 0.99 (0.97-1.01) for overweight and 1.17 (1.14-1.20) for obesity class I, increasing across higher obesity classes. Excess risk was largely mediated by diabetes, hypertension, and prior cardiovascular disease. CONCLUSIONS: Obesity was associated with increased risk of MACE, partly mediated by obesity-related risk factors. The findings suggest that previously reported "obesity paradoxes" may reflect differences in confounder adjustment, handling of mediators, patient populations, and survivor bias.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (63 words).
Try re-searching for a better abstract.
| Reference Key |
openalex_W7172520549
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Peder af Geijerstam, Pontus Hedberg, Nermin Hadziosmanovic, Claes Held, Tomas Jernberg, Moman A. Mohammad, Elmir Ömerovic, Emil Hagström, Joakim Alfredsson |
| Journal | european journal of preventive cardiology |
| Year | 2026 |
| DOI |
10.1093/eurjpc/zwag410
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.