RSV shapes serotype-specific invasive pneumococcal disease dynamics in children: an observational study

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ID: 323746
2026
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Abstract
Abstract Background Pneumococcal nasopharyngeal colonization is the first step toward invasive pneumococcal disease (IPD). Respiratory syncytial virus (RSV) may trigger IPD, particularly for serotypes with low disease potential. We aimed to analyse the distribution of pneumococcal serotypes among paediatric IPD according to RSV circulation level. Methods We used data from three continuous French surveillance systems on IPD, pneumococcal carriage and RSV infections from 2008 to 2023. Based on the RSV epidemics threshold, we assessed the proportion of each serotype among IPD, depending on “RSV season” and “non-RSV season”. We assessed the correlation between the likelihood of serotype-specific involvement in IPD according to non-RSV season vs RSV season and the estimated disease potential of each serotype. Results Among 4,574 IPD cases, the serotype distribution strongly varied during non-RSV season vs RSV season. The lower the disease potential of serotypes, the more RSV circulation enhanced their involvement in IPD (Rho=0.60, CI95% 0.28 to 0.80, p-value = 0.0012). Conclusions The role of RSV in triggering IPD strongly varies across pneumococcal serotypes. The impact of RSV-targeted interventions should be evaluated in light of these data.
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Authors Inès Fafi, Corinne Lévy, Emmanuelle Varon, Robert Cohen, Stéphane Béchet, Zaba Valtuille, André Birgy, Stéphane Bonacorsi, Jean-François Delobbe, Christophe Batard, Zein Assad, Manon Jaboyedoff, Léa Lenglart, Romain Basmaci, Naïm Ouldali
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag401
URL
https://doi.org/10.1093/infdis/jiag401
Keywords Keywords not found

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