An Exploratory Study of Host Plasma Proteomic Signatures that Distinguish Secondary and Early Latent Syphilis in Adults

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ID: 323670
2026
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Ranked #140 of 208 articles by views in Open forum infectious diseases

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Abstract
Abstract Syphilis diagnostics struggle to distinguish active from treated disease. Using tandem-mass-tag proteomics on plasma from 10 secondary and early latent syphilis cases and 8 matched controls, we identified 54 differentially regulated proteins categorized under several biological pathways. Those exploratory findings support proteomics as a tool for developing novel syphilis diagnostics.
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openalex_W7172416221 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cody Chou, Shad R. Morton, Kelika A. Konda, Silver K. Vargas, Michael Reyes-Díaz, Francesca Rosalia De Maria Vasquez Vasquez, Carlos F. Cáceres, Jeffrey D. Klausner, Trey Toombs, Rushdy Ahmad, Lao‐Tzu Allan‐Blitz
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag498
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