Framingham risk score and its relationship with cardiorespiratory fitness and physical activity levels in older breast cancer survivors

Clicks: 3
ID: 323477
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #259 of 282 articles by views in European heart journal supplements : journal of the European Society of Cardiology

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 282 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Older breast cancer (BC) survivors are at increased risk of developing cardiovascular disease (CVD). The Framingham Risk Score (FRS) is a widely used tool for estimating 10-year risk of atherosclerotic CVD or myocardial infarction. Cardiorespiratory fitness, objectively measured as peak oxygen uptake (VO2peak), is a strong predictor of all-cause and CVD mortality. Despite this, the relationship between VO2peak, physical activity levels, and traditional risk factors used to guide long-term CVD risk in older BC survivors remains understudied. Purpose This study aimed to examine whether cardiorespiratory fitness and physical activity levels are associated with 10-year FRS estimates in older, long-term BC survivors. Methods BC survivors (≥60 years) who were greater than one year post anthracycline or trastuzumab therapy and without established CVD were enrolled. Cardiorespiratory fitness was assessed using gas- exchange analysis during a graded maximal exercise test performed on a stationary cycle ergometer and weekly physical activity was assessed from a self-report questionnaire. FRS was determined from health history questionnaires (deriving age, smoking history and medication use), fasted blood draw (HDL- and total cholesterol) and resting blood pressure measurement (systolic blood pressure) in order to calculate 10-year risk scores. Pearsons or Spearmans correlation coefficients were used to examine associations between 10-year FRS and VO2peak and self reported physical activity levels. Data are reported as mean ± SD or median (IQR), and statistical significance was set at α < 0.05. Results Seventy-one participants were included in the analysis (mean age: 69 ± 5 years, BMI: 27.4 ± 5.4 kg/m2, time post treatment: 13.9 ± 6.1 years). Mean VO2peak was 19.1 ± 4.5 mL/kg/min, and participants self-reported 210 (70-300) minutes of exercise per week. The median composite FRS score was 13.0 (9.3-16.0), corresponding to a 10-year FRS of 10.0 (5.6-15.9). No significant association was found between FRS and VO2peak (ρ = -0.076, p = 0.529). In contrast, self-reported physical activity was significantly, albeit weakly, associated with 10-year FRS (ρ = −0.240, p = 0.047). Conclusion Despite its wide-spread clinical use, 10-year FRS score is not related to VO2peak in older BC survivors, despite VO2peak being a major predictor of all-cause and CVD mortality. Future risk stratification should consider adding physical activity and VO2peak alongside FRS to improve CVD prediction in older long-term BC survivors.Correlations between primary outcomes
Reference Key
openalex_W7172298395 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors N R Weeldreyer, S J Foulkes, S Paterson, E Pituskin, M J Haykowsky
Journal European heart journal supplements : journal of the European Society of Cardiology
Year 2026
DOI
10.1093/eurheartjsupp/suag097.160
URL
https://doi.org/10.1093/eurheartjsupp/suag097.160
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.