Bioprosthetic aortic valve replacement in patients under 60 years – 3-year safety results from the indure registry

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ID: 322816
2026
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Ranked #25 of 148 articles by views in Interdisciplinary CardioVascular and Thoracic Surgery

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Abstract
OBJECTIVES: We report three-year safety and clinical outcomes in patients younger than 60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS: The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, multicentre registry to assess clinical outcomes of patients under 60 years. Patients with planned surgical aortic valve replacement with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance, and quality-of-life (QoL) at three years were assessed. RESULTS: The study cohort included 415 patients with a mean age of 53.5 years, 76.9% being male and 27.1% in New York Health Association (NYHA) class III/IV. Outcomes after three years included cardiovascular-related mortality (0.4%), thromboembolic events (0.6%), valve-related bleeding (0.0%) and new permanent pacemaker implantation (0.4%). QoL increased over the time course of the study from baseline to three-year follow-up. Three-year freedom from all-cause mortality was 95.4% (95% CI 93.3-97.6), and 84.5% were NYHA I versus 22.0% at baseline. No patient developed haemodynamic valve deterioration stage 3. The mean aortic pressure gradient was 13.7 mmHg at three years, and the mean effective orifice area was 1.8 cm. CONCLUSIONS: The three-year data from the INSPIRIS RESILIA valve demonstrate reassuring safety findings and stable haemodynamic performance as well as a high QoL.
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Authors Ruggero De Paulis, Jean-Christian Roussel, Michael Borger, Sami Kueri, Pierluigi Stefano, Martin Andreas, Thierry Langanay, Alexis Théron, Frieda Maria Kainz, Martin Grabenwöger, Philippe Demers, Renzo Pessotto, Wouter van Leeuwen, Thierry Bourguignon, S. Cánovas, Giovanni Mariscalco, Enrico Coscioni, Francois Dagenais, Ranjit Deshpande, Eleonora Penza, Matthias Eden, Peter Bramlage, Beate Botta, Lena Zimmermann, Nataliya Trushina, Bart Meuris
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Journal Interdisciplinary CardioVascular and Thoracic Surgery
Year 2026
DOI
10.1093/icvts/ivag208
URL
https://doi.org/10.1093/icvts/ivag208
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