Feasibility of a Contactless, Self-Directed, Home-Based Dim-Light Melatonin Onset Protocol: The Circadia Pilot Study
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ID: 322615
2026
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Abstract
Abstract Study Objectives To test the feasibility of a self-directed, in-home, contactless salivary Dim Light Melatonin Onset (DLMO) assessment protocol to remotely measure endogenous circadian phase in participants with circadian rhythm disorders and healthy controls. Methods The 4–6-week protocol involved sleep, activity, and light tracking, sleep diaries, questionnaires, and two self-directed at-home salivary sample collections for DLMO one week apart with objective compliance measures. Individuals participated remotely using an online portal and received a mailed kit. The study population included five cases with Circadian-Rhythm Sleep-Wake Disorders and five controls ages 27-63. Results Salivary DLMO times could be calculated for 14/20 assessments, resulting in 8/10 participants with at least 1 valid DLMO and 6/10 having valid DLMOs for both. Failures in DLMOs resulted from compliance errors (e.g., bright light levels) or consistently below/above threshold melatonin levels. After completing the DLMO collections, 70% of participants felt confident after completing DLMO 1, while 90% felt confident after DLMO 2. DLMO occurred on average at 24.08 hours (SEM = 1.10 hours) for 4 participants with Delayed Sleep Wake Phase Disorder, and at 21.37 hours (SEM = 0.71 hours) for 5 controls. The first and second DLMOs were strongly correlated (r = 0.98, p < 0.001). Conclusions Our results indicate that contactless, self-directed, at-home DLMO assessments are feasible, reliable and capable of detecting clinically relevant differences in circadian timing. The current protocol may serve as a framework to reliably and scalably assess circadian phase in both clinical and general populations.
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| Authors | Gregory Bormes, Jessica J Love, Angus C. Burns, Oluwaseun Akeju, J. C. Cherry, Nisha Kantesaria, Lovemore Kunorozva, Salim Qadri, Shadab A. Rahman, Frank A. J. L. Scheer, Brandon Westover, John Winkelman, Richa Saxena, Jacqueline M. Lane |
| Journal | SLEEP Advances |
| Year | 2026 |
| DOI |
10.1093/sleepadvances/zpag081
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| URL | |
| Keywords | Keywords not found |
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