Hereditary Angioedema: On-demand Treatment and Long-term Prophylaxis – A Global Reality
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ID: 322534
2026
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Abstract
Abstract Hereditary Angioedema (HAE) is a rare disorder of recurrent swellings of the subcutaneous and/or mucosal tissues due to defects in the contact system regulation of bradykinin production. The swellings can be disfiguring, cause debilitating abdominal pain, or be fatal with laryngeal obstruction. Over the last decade there has been immense successes in management of HAE owing to development of drugs targeting the contact system. This review focuses on management of HAE due to C1-INH deficiency/dysfunction including a global perspective which is under-represented in the literature. HAE with normal C1-INH is outside the scope of this article. The review provides summaries of clinical trials that has led to licensing of new HAE medications and discusses access to these modern drugs from a global perspective.
| Reference Key |
openalex_W7171083464
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|---|---|
| Authors | Cassim Akhoon, Sorena Kiani‐Alikhan |
| Journal | Clinical & Experimental Immunology |
| Year | 2026 |
| DOI |
10.1093/cei/uxag043
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| URL | |
| Keywords | Keywords not found |
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