Utility of p53 Immunohistochemistry in Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: A Retrospective Study of 50 Cases

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ID: 322476
2026
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Abstract
p53 immunohistochemistry shows a high frequency of aberrant expression in atypical fibroxanthoma and pleomorphic dermal sarcoma, reflecting underlying UV-associated TP53 alterations. While not specific, p53 serves as a useful adjunct in challenging cases, particularly in distinguishing residual tumour from reactive changes.
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Authors Ghadah Al-Sharbatee, Maged Daruish, Daniella Wu, Saleem Taibjee
Journal clinical and experimental dermatology
Year 2026
DOI
10.1093/ced/llag320
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