Associations of Actigraphic Sleep Parameters with Adipokines in Older Adults in the Baltimore Longitudinal Study of Aging

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ID: 322465
2026
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Abstract
Abstract Study objectives Sleep and adipokines are important regulators of cardiometabolic health, yet their relationship in older adults remains poorly understood. We examined cross-sectional and longitudinal associations of actigraphic sleep parameters with adipokine levels among older adults and explored sex and central obesity as potential moderators. Method We studied 350 participants aged ≥ 60 years (mean = 74.8±8.3 years, 48.9% females, 19.4% Black) from the Baltimore Longitudinal Study of Aging who completed 6.5±1.1 nights of wrist actigraphy and provided fasting plasma for adipokine measurements. Predictors were total sleep time (TST), sleep onset latency, wake after sleep onset, sleep efficiency, and average wake bout length (AWBL); outcomes were adiponectin and leptin levels. Results At baseline, longer AWBL was associated with lower adiponectin (B = -2.02, 95% CI [-3.61, -0.42], p = 0.013) and leptin (B = -3.14, [-5.25, -1.03], p = 0.004) in fully adjusted models. Longer TST, modeled continuously, predicted a greater increase in adiponectin levels over time (B=0.26, [0.081, 0.44], p=0.007), and short TST (< 6hours) was linked to subsequent decline in adiponectin (B=-0.90, [-1.72, -0.079], p=0.038). Sex and central obesity moderated the baseline AWBL-adiponectin associations, which were significant in females (B = -3.92, [-6.25, -1.59], p = 0.001) and those with lower central obesity (B = -6.98, [-10.43, -3.53], p < 0.001). Conclusions Longer sleep duration and shorter wake bouts are linked to more favorable adipokine profiles in older adults, especially in females and those with lower central obesity. Sleep may exert cardiometabolic effects through adipokines in older adults.
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openalex_W7170170152 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhikui Wei, Yiwei Yue, Jill A. Rabinowitz, Marc Kaizi-Lutu, Mark N. Wu, Chee W. Chia, Toshiko Tanaka, Eleanor M. Simonsick, Luigi Ferrucci, Adam P. Spira
Journal SLEEP Advances
Year 2026
DOI
10.1093/sleepadvances/zpag082
URL
https://doi.org/10.1093/sleepadvances/zpag082
Keywords Keywords not found

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