Does a 10-puff bout reflect natural puffing patterns for electronic nicotine delivery systems?

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ID: 322120
2026
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Abstract
Abstract Introduction An important research gap is how users of electronic nicotine delivery systems (ENDS) group puffs together, and whether that pattern accurately reflects the standardized 10-puff procedure often employed in laboratory-based work. Previously defined “puff cluster” parameters were applied to data from our own work and then the patterns compared to those published elsewhere. Methods For all studies (N=8), the same definition of a puff cluster was used (number of puffs separated by <60 seconds), as was the same cluster categorizations: 1 puff (single), 2-5 puffs (short), 6-10 puffs (medium), or >10 puffs (long). Descriptive analyses included the average frequency, average number of puffs taken, and percent of total puffs/session, for each cluster type. Differences in cluster patterns as a function of pre-session ENDS abstinence and puffing bout length were explored. Results Single and small clusters were the most common in 7 of 8 studies; the average number of cluster types was 9.02 (SD=7.55) single clusters, 5.96 (SD=4.02) small clusters, 0.94 (SD=0.74) medium clusters, and 0.49 (SD=0.44) large clusters. Small clusters made up the largest percentage of total puffs within a session (M=37.12%), followed by single puffs (M=28.55%), large clusters (M=17.41%), and medium clusters (M=16.92%). Puff cluster patterns were similar regardless of the pre-session ENDS abstinence requirement and the ENDS puffing bout duration. Conclusions Single puffs and small clusters were the predominant cluster types, accounting for accounting for 67.0% of all puffs. The 10-puff bout typically used in laboratory work to standardize product use does not represent naturalistic ENDS puffing.
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Authors Melissa D. Blank, Nicholas J. Felicione, Alison Breland, Andrea R. Milstred, Caroline O. Cobb
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Journal nicotine & tobacco research : official journal of the society for research on nicotine and tobacco
Year 2026
DOI
10.1093/ntr/ntag165
URL
https://doi.org/10.1093/ntr/ntag165
Keywords Keywords not found

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