Lactiplantibacillus plantarum NCHBL-004 improves intestinal motility and modulates serotonergic gene expression in a loperamide-induced constipation model
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ID: 321767
2026
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Abstract
Slow-transit constipation (STC) is characterized by reduced colonic motility, impaired smooth muscle function, and altered mucosal signaling. Among these pathways, mucosal serotonin (5-HT), mainly produced by enterochromaffin cells, contributes to intestinal motility regulation. In a loperamide-induced constipation model in male C57BL/6J mice, we evaluated the effects of Lactiplantibacillus plantarum NCHBL-004 on bowel function and associated molecular changes. Compared with loperamide-treated mice, live NCHBL-004 at 1×10⁹ CFU improved fecal output and gastrointestinal transit and partially preserved fecal water content, whereas the lower live dose and heat-killed preparation showed no significant effects. These functional changes were accompanied by preservation of colonic muscularis thickness and increased expression of smooth muscle-associated markers, including Acta2 and Myh11. NCHBL-004 also modulated mucosal serotonergic gene expression, as indicated by increased Tph1, which encodes a key enzyme for 5-HT synthesis, and decreased Slc6a4, which encodes the serotonin transporter involved in 5-HT reuptake. Overall, these findings suggest that live NCHBL-004 improves intestinal motility in loperamide-induced constipation, with associated changes in colonic smooth muscle phenotype and mucosal serotonergic regulation.
| Reference Key |
openalex_W7169837037
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| Authors | Kim WI, Taesung Lee, C S Kim, Yong Wook Kim, In-Su Seo, Ahn Sj, Ji-Yeong Kim, Sang-Eun Jung, Geun-Woo Kim, Eun-Jung Song, Ah‐Ra Jang, HongBum Koh, Jong‐Hwan Park |
| Journal | letters in applied microbiology |
| Year | 2026 |
| DOI |
10.1093/lambio/ovag063
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| URL | |
| Keywords | Keywords not found |
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