First case of the novel GrOwnValve procedure – a case report

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ID: 321657
2026
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Abstract
Abstract Background Current pulmonary valve replacement strategies rely on bioprosthetic or mechanical prostheses, which are limited by structural valve degeneration, reduced durability, or the need for lifelong anticoagulation. Tissue-engineered alternatives have been proposed but remain constrained by complex manufacturing processes and limited intraoperative applicability. We report the first clinical application of the GrOwnValve procedure, a novel approach for intraoperative fabrication of a patient-specific pulmonary valve prosthesis using autologous tissue and 3D-printed moulds. Case summary A 35-year-old man with severe homograft stenosis following Ross procedure (peak gradient 115 mmHg) underwent implantation of a patient-specific GrOwnValve prosthesis. Patient-specific moulds were generated from preoperative computed tomography data. During the intervention, autologous pericardium was harvested, shaped, and stabilized using a novel alternative to glutaraldehyde before assembly onto a transcatheter stent frame and implantation. The procedure was completed without complications. At follow-up, exercise capacity improved from 180 to 196 W. Cardiac magnetic resonance imaging demonstrated a reduction in peak gradient (115 to 16 mmHg), regurgitant fraction (20% to 10%), and right ventricular end-diastolic volume index (196 to 133 mL/m2). Echocardiography showed decreasing transvalvular velocity (5.08 to 1.89 m/s) and increasing pressure half-time (158 to 350 ms), indicating sustained valve function. Conclusion This case demonstrates the feasibility of intraoperative manufacturing and transcatheter implantation of a patient-specific autologous pulmonary valve prosthesis. Early follow-up showed favourable hemodynamic performance and signs of right ventricular reverse remodelling. While long-term durability remains to be established, this first-in-human case highlights a novel treatment concept that combines autologous tissue, patient-specific valve design, and transcatheter implantation.
Reference Key
openalex_W7169762547 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alexander Breitenstein‐Attach, Marvin Steitz, Boris Schmitt
Journal European Heart Journal - Case Reports
Year 2026
DOI
10.1093/ehjcr/ytag548
URL
https://doi.org/10.1093/ehjcr/ytag548
Keywords Keywords not found

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