Age- and Sex-Dependent Heterogeneity in Mumps Virus Immunity Among US Blood Donors Born Between 1928-1993

Clicks: 2
ID: 321553
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #282 of 427 articles by views in The Journal of infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 427 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Despite widespread vaccination, mumps outbreaks continue to occur, raising concerns about waning immunity and strain-specific differences in neutralizing antibody responses. Methods We evaluated seroprevalence, total antibody levels, and neutralization capacity against the vaccine (JL5) and outbreak (genotype G) mumps virus (MuV) strains from 187 US blood donors born between 1928 and 1993. Associations with age, sex, and donation site, were analyzed. Results MuV IgG seropositivity was 84.5% and did not differ by age, sex or blood donation site. However, ELISA index values increased with age, with individuals ≥60 years exhibiting higher total MuV antibody levels than donors ≤30 years, primarily driven by males. For most donors, neutralization was consistently higher against JL5 than genotype G, and ELISA index values positively correlated with neutralization titers for both strains. Age positively associated with genotype G neutralization but not JL5, with a significant increase in the genotype G:JL5 neutralization ratio with age (p<0.0001). Males exhibited significantly higher neutralization titers than females against both strains, with older males exhibiting greater neutralization against Genotype G than both age-matched females and younger males. Conclusions Our study suggests that antibody quantity alone does not fully predict mumps protection, and factors such as sex may contribute to functional differences in immunity. Our findings highlight potential gaps in protection against circulating strains, possibly contributing to ongoing outbreaks despite high vaccination coverage. The age-dependent increase in total MuV antibodies, which correlates with genotype G neutralization, supports that cumulative antigenic exposure may shape the breadth of MuV-specific immunity over time.
Reference Key
openalex_W7169678682 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Aum R. Patel, Axel Guzmán-Solís, Gregory A. Foster, David Krysztof, Susan L. Stramer, Benhur Lee, Jean K. Lim
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag379
URL
https://doi.org/10.1093/infdis/jiag379
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.