Streamlining mavacamten treatment pathways: clinical and economic evaluation of point-of-care CYP2C19 genotyping
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ID: 321066
2026
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Abstract
Abstract Objectives To evaluate whether point-of-care (POC) CYP2C19 genotyping streamlines mavacamten initiation. Methods Pre–post service evaluation in a tertiary cardiology service; 10 consecutive patients underwent parallel laboratory and POC genotyping. Outcomes were concordance, turnaround time, number of appointments, patient preference, and costs. Key findings Concordance was 100%. Laboratory turnaround was 10 days; POC run time 63 min. Appointments fell from three to one. Costs decreased by £245.76 per patient for the health service and £118 for patients; break-even was about 3–4 patients per year. Conclusions POC genotyping is feasible, improves efficiency and experience, and offers a credible economic case.
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| Authors | Anisha Patel, Jessica Gadsby, Harshil Dhutia, Helen Knight, Julian Barwell, Hussain Mulla |
| Journal | international journal of pharmacy practice |
| Year | 2026 |
| DOI |
10.1093/ijpp/riag091
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| URL | |
| Keywords | Keywords not found |
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