An 18-Month Prospective Evaluation of a Novel Hyaluronic Acid Filler (YYS 720) for Three-Dimensional Nasal and Chin Augmentation

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ID: 320993
2026
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Abstract
Abstract Background Hyaluronic acid (HA) fillers typically require frequent reinjections. Next-generation fillers like the Y-phasic YVOIRE® Y-solution (YYS) 720 require extended clinical validation to confirm their long-term performance and safety. Objectives This study evaluated 18-month clinical outcomes, safety, and satisfaction of YYS 720 for nasal and chin augmentation. Methods In this prospective, single-arm study, 16 Korean subjects received YYS 720 for the nose (n = 12) and chin (n = 7). Efficacy was evaluated via practitioner-assessed Global Aesthetic Improvement Scale (GAIS), patient-reported FACE-Q™ questionnaires, and objective 3D morphometric analysis. Safety was monitored via adverse event reporting and Visual Analogue Scale (VAS) pain scores. Results The GAIS responder rate was 100% through Month 12 and 84.21% at Month 18. FACE-Q scores significantly increased until Month 18 for the nose (80.67 ± 24.35, p = 0.0015) and Month 6 for the chin (86.00 ± 18.43, p = 0.0156). 3D analysis showed significant long-term improvements, with 1.73 ± 1.11 mL chin volume at Month 18 (p = 0.0061) and a 3.99 ± 2.81˚ nasofrontal angle increase at Month 12 (p = 0.0015) compared to baseline. The mean VAS score was low (1.69 ± 1.40). Only transient swelling and tenderness occurred in four subjects, with no long-term delayed or serious adverse events. Conclusions This pilot study provides preliminary evidence supporting the 18-month efficacy and safety of YYS 720. Given its pilot nature, these findings do not constitute claims of long-term reliability or durability, which were not formally assessed.
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Authors Minjeong Son
Journal Aesthetic Surgery Journal Open Forum
Year 2026
DOI
10.1093/asjof/ojag146
URL
https://doi.org/10.1093/asjof/ojag146
Keywords Keywords not found

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