The case for N-acetylcysteine in dengue associated liver injury: time for definitive evidence

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ID: 320056
2026
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Abstract
Abstract Dengue-associated liver injury is common, prognostically significant, and associated with high mortality at severe thresholds. Oxidative stress is a key, potentially modifiable mechanism. N-acetylcysteine has strong biological plausibility and supportive preclinical data, but clinical evidence remains limited, underscoring the need for well-designed randomised trials to inform practice and policy.
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openalex_W7167585963 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Angela McBride, Nguyen Lam Vuong, Sudeep Adhikari, Su Myat Han, Po Ying Chia, Huynh Trung Trieu, Phung Khanh Lam, Ho Quang Chanh, Giri Shan Rajahram, Peter Horby, Tsin Wen Yeo, Evelyne Kestelyn, James A Watson, Truong Ngoc Trung, Sophie Yacoub
Journal Open forum infectious diseases
Year 2026
DOI
10.1093/ofid/ofag421
URL
https://doi.org/10.1093/ofid/ofag421
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