Joint modelling of longitudinal HRQoL data accounting for the risk of competing dropouts

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ID: 319937
2026
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Abstract
Abstract In cancer clinical trials, health-related quality of life (HRQoL) is an important endpoint, providing information about patients’ well-being and daily functioning. However, missing data due to premature dropout can lead to biased estimates, especially when dropouts are informative. This paper introduces the JMIRT approach, a novel tool that efficiently analyses multiple longitudinal ordinal categorical data while addressing informative dropout. Within a joint modelling framework, this approach connects a latent variable, derived from HRQoL data, to cause-specific hazards of dropout. Unlike traditional joint models, which treat longitudinal data as a covariate in the survival submodel, our approach prioritizes the longitudinal data and incorporates the log dropout risks as covariates in the latent process. This leads to a more accurate analysis of longitudinal data, accounting for potential effects of dropout risks. Through extensive simulation studies, we demonstrate that JMIRT provides robust and unbiased parameter estimates and highlight the importance of accounting for informative dropout. We also apply this methodology to HRQoL data from patients with progressive glioblastoma, showcasing its practical utility.
Reference Key
openalex_W7167715223 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hortense Doms, Philippe Lambert, Catherine Legrand
Journal Journal of the Royal Statistical Society Series C (Applied Statistics)
Year 2026
DOI
10.1093/jrsssc/qlag036
URL
https://doi.org/10.1093/jrsssc/qlag036
Keywords Keywords not found

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