Inflammatory bowel disease in the aging population

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ID: 319915
2026
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Abstract
Abstract As the prevalence of inflammatory bowel disease (IBD) rises rapidly among older adults, gastroenterologists and other health care providers increasingly face challenges in managing age-related comorbidities, polypharmacy, and functional impairments such as frailty and sarcopenia. This narrative review proposes a dual approach to management by optimizing care for patients aged >60 years while promoting the healthy aging of those aged 40-60 years. For patients aged >60 years, we emphasize prescribing effective corticosteroid-sparing medications to control inflammation, conducting medication reconciliations to assess appropriateness and drug interactions, and evaluating baseline hepatic and renal function for necessary dose adjustments. For patients aged 40-60 years, we advise regular screening and nutritional counseling to delay the onset of age-related comorbidities and recommend targeting endoscopic remission to modify the disease course and reduce complications and disability later in life. Given that patients with IBD receiving long-term immunosuppression are at increased risk of infections, adherence to age-appropriate vaccination schedules is also recommended. A proactive and personalized approach to disease management has the potential to optimize quality of life for older adults with IBD.
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openalex_W7167732152 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Adam S. Faye, Bharati Kochar, D Y Choi, Thais Gift, Kendra Kamp, Nicholas L. Rider, Gilaad G. Kaplan
Journal inflammatory bowel diseases
Year 2026
DOI
10.1093/ibd/izag122
URL
https://doi.org/10.1093/ibd/izag122
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