One-year dynamics of clinical activity during biologics therapy in patients of ulcerative colitis

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ID: 319687
2026
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Abstract
Abstract Background Longitudinal trajectories and the optimal timing for evaluating clinical activity remains unclear in ulcerative colitis (UC) patients receiving biologics. Methods This study included 2,705 UC patients from five trials and collected 28,807 records of partial Mayo scores (PMS) from baseline to week 52. Latent class growth mixed model was performed to construct one-year PMS trajectories. Logistic regression assessed the association between PMS trajectories and one-year therapeutic outcomes, and endoscopic remission was the primary outcome. Spearman correlation was utilized to identify the timepoints of PMS most correlated with the trajectories. Results Five trajectories of clinical activity were identified, including rapid remission (n = 590, 21.8%), delayed remission (n = 316, 11.7%), mild improvement (n = 748, 27.7%), slow improvement (n = 915, 33.8%), and relapse-fluctuation (n = 136, 5.0%) groups. Endoscopic and histological remission rates exhibited a progressive decline across trajectory groups, with the highest probability in the rapid remission group and sequentially lower probabilities in the delayed remission, mild/slow improvement, and relapse-fluctuation groups (p < 0.001). Week-20 PMS demonstrated the strongest correlation with clinical activity trajectories (correlation coefficient = 0.7867, p < 0.001), with an area under curve of 0.9311 (95%CI: 0.9183,0.9440). Furthermore, Week-20 PMS could independently predicted one-year endoscopic (aOR[95%CI] 0.59[0.54, 0.65], p < 0.001) and histological (aOR[95%CI] 0.61[0.53-0.70], p < 0.001) remission. Conclusions UC patients receiving biologics would exhibit five distinct trajectories of clinical activity. Week 20 is a potential intermediate timepoint for clinical activity assessment to inform long-term outcomes.
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Authors Yizhe Tie, Fengyuan Su, Jianwu Zhang, Minhui Zheng, Ningyi Li, Jieqi Zheng, Minhu Chen, Rirong Chen, Li Li, Shenghong Zhang
Journal Crohn s & Colitis 360
Year 2026
DOI
10.1093/crocol/otag074
URL
https://doi.org/10.1093/crocol/otag074
Keywords Keywords not found

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