scPD: a Python package for inferring continuous population dynamics from single-cell snapshot data

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ID: 319497
2026
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Abstract
Abstract Summary Quantitative inference of developmental dynamics from single-cell snapshot data is essential for disentangling differentiation and proliferation processes. The pseudodynamics framework provides a principled approach to this problem but lacks a scalable and user-friendly implementation for modern single-cell workflows. Here, we present scPD, a high-performance Python toolkit that implements and extends the pseudodynamics framework within the Scanpy ecosystem. scPD implements an efficient and scalable inference strategy, enabling the analysis of large-scale single-cell datasets with substantially reduced computational cost. This scalability enables kinetic parameter inference to be readily integrated into standard Python-based pipelines, facilitating quantitative characterization of population dynamics from time-resolved single-cell data. Availability and implementation scPD is implemented in Python and is freely available as an open-source package on GitHub at https://github.com/yys-arch/scPD. Documentation and example notebooks are provided. The data used in this study are publicly available under DOI: 10.5281/zenodo.18337517. Supplementary information Supplementary data are available at Bioinformatics advances online.
Reference Key
openalex_W7167076887 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yusong Yin, Hong Qi, Huan Hu
Journal Bioinformatics advances
Year 2026
DOI
10.1093/bioadv/vbag188
URL
Keywords Keywords not found

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