Cross-reactivity of Cryptococcal Antigen Lateral Flow Assay with Basidiomycetous Yeasts

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ID: 319343
2026
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Abstract
The cryptococcal antigen lateral flow assay (CrAg LFA) is a widely available point of care test for the diagnosis of cryptococcal meningitis. Although there have been some reports of cross-reactivity with Trichosporon species, the extent of cross-reactivity among basidiomycetous yeasts has not been widely explored. We tested a range of basidiomycete yeast isolates using a CrAg LFA to examine potential cross-reactivity, with positive results for all isolates belonging to Trichosporon and Naganishia species, and in some isolates of Cutaneotrichosporon, Filobasidium and Ustilago species. While these species rarely cause invasive infection, the potential for cryptococcal antigen cross-reactivity should be considered.
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openalex_W7166685844 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors S Kidd, Catriona L Halliday
Journal medical mycology
Year 2026
DOI
10.1093/mmy/myag070
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