NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris

Clicks: 1
ID: 319209
2026
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal

Ranked #416 of 430 articles by views in The Journal of infectious diseases

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 430 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Abstract Background Cutibacterium acnes strains vary in virulence and inflammatory potential in acne vulgaris, but the role of the bacterial ability to induce neutrophil extracellular traps (NETs) in acne is unclear. Methods We collected 18 clinical isolates from acne patients and healthy controls and analyzed the correlation between C. acnes NET-inducing ability and bacterial virulence involved in acne vulgaris pathogenicity. Results Eighteen clinical strains were classified into 17 IA1 and 1 IA2 phylotypes. Supernatants from five acne-associated strains exhibited marked NET-inducing activity, which was strongly correlated with cytokine production and reactive oxygen species generation. The NET-inducing capacity of supernatants was also positively correlated with bacterial hemolytic activity against human erythrocytes and biofilm formation. In a mouse ear model, NET-inducing strains caused more-severe lesions than NET-noninducing strains. Whole-genome sequencing revealed substantial genetic variation between the NET-inducing strain (C009) and NET-noninducing ATCC strain. Conclusion These findings suggest that NET induction represents one of virulence-associated phenotypes linked to pathogenicity in C. acnes-induced acne vulgaris.
Reference Key
openalex_W7166850909 Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yi‐Hsien Shih, Chih-Chieh Hsu, Che-Hao Hsu, Pei-Yun Kuo, Yue Wang, W-H Lee, Chiau‐Jing Jung
Journal The Journal of infectious diseases
Year 2026
DOI
10.1093/infdis/jiag343
URL
https://doi.org/10.1093/infdis/jiag343
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.