Sex differences in photon-counting CT findings across hypertrophic phenotypes
Clicks: 1
ID: 319099
2026
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
0.0
/100
1 views
0 readers
AI Quality Assessment
Not analyzed
Readership in this journal
Ranked #19 of 47 articles by views in European Heart Journal - Imaging Methods and Practice
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Abstract Background Photon-counting computed tomography (PCCT) enables simultaneous assessment of left ventricular morphology, function, and myocardial tissue characterization. Whether sex influences PCCT findings across hypertrophic phenotypes remains uncertain. Methods We studied consecutive adults with a left ventricular hypertrophic phenotype undergoing PCCT. Patients were classified as hypertrophic cardiomyopathy (HCM), transthyretin amyloid cardiomyopathy (ATTR-CM), or secondary left ventricular hypertrophy (LVH). Sex differences in PCCT-derived left ventricular mass index, volumes, ejection fraction, late iodine enhancement (LIE), and extracellular volume (ECV) were assessed overall and by etiology. In patients with clinically indicated cardiovascular magnetic resonance (CMR) within ±12 months, sex effects on CT-CMR agreement were also evaluated. Results Among 182 patients, 50 were women and 132 were men; 83 had paired PCCT-CMR data. In the overall cohort, women had lower left ventricular mass index, smaller left ventricular volumes, higher ejection fraction, slightly lower ECV, and lower LIE extent than men. In HCM, women and men showed similar wall thickness, left ventricular mass, LIE burden, and ECV. In secondary LVH, women had smaller volumes and higher ejection fraction, without meaningful differences in tissue markers. In ATTR-CM, women appeared less remodeled and less infiltrative, although only four women were included. CT-CMR agreement for wall thickness, left ventricular mass, ejection fraction, scar extent, and ECV was similar in women and men. Diagnostic ECV thresholds were also consistent across sexes. Conclusions Sex influences PCCT hypertrophic phenotypes mainly through remodeling and functional adaptation rather than major differences in tissue characterization. CT-CMR agreement and diagnostic ECV thresholds appear robust across sexes.
| Reference Key |
openalex_W7166535214
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Carmelo De Gori, Alberto Aimo, Yu Fu Ferrari Chen, F. Pignatelli, Mariaelena Occhipinti, Matilda Muça, Denisa Simona Zai, Alessandro Campora, Vincenzo Castiglione, Andrea Barison, Roberta Poletti, Silvia Maffei, Alberto Clemente, Giancarlo Todiere, Giuseppe Vergaro, Michele Emdin |
| Journal | European Heart Journal - Imaging Methods and Practice |
| Year | 2026 |
| DOI |
10.1093/ehjimp/qyag120
|
| URL | |
| Keywords | Keywords not found |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.