Immunoglobulin A vasculitis in association with invasive meningococcal disease: a case report.
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ID: 318942
2026
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Abstract
Abstract Immunoglobulin A vasculitis (IgAV) is uncommon in adults and is frequently associated with an identifiable trigger, most often infection. Invasive meningococcal disease (IMD) is a rare but life-threatening infection caused by Neisseria meningitidis. We report the case of an 18-year-old Indigenous Australian woman who presented with fever, purpuric rash, ankle synovitis, abdominal pain, and systemic inflammation. Skin biopsy demonstrated leukocytoclastic vasculitis with IgA deposition on immunohistochemistry, and blood cultures subsequently identified N. meningitidis serogroup B. Cerebrospinal fluid studies were unremarkable. The patient was treated with intravenous ceftriaxone, with complete clinical resolution and no recurrence at six-month follow-up. This case highlights a previously unreported association between IgAV and IMD in an adult patient and expands the spectrum of infectious triggers associated with adult-onset IgAV.
| Reference Key |
openalex_W7166040970
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| Authors | Joseph M. Danicic, Burcu Isler, Jennifer Ng |
| Journal | Modern Rheumatology Case Reports |
| Year | 2026 |
| DOI |
10.1093/mrcr/rxag054
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| URL | |
| Keywords | Keywords not found |
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